4-(3,4-DIMETHOXYPHENETHYL)-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE synthesis
1synthesis methods
- Product Name:4-(3,4-DIMETHOXYPHENETHYL)-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE
- CAS Number:37508-41-1
- Molecular formula:C19H21NO4
- Molecular Weight:327.37
Yield:37508-41-1 80 %
Reaction Conditions:
at 145 - 150;
Steps:
Imides 11, 12, and 13
General procedure: A mixture of 0.27 g (1.5 mmol) of 2-(3,4-dimethoxyphenyl)ethanamine (3) and 1.5 mmol of thoroughly ground anhydride 8, 9, or 10 (0.25, 0.4, or 0.41 g, respectively) was heated at 145-150°C on an oil bath for 0.5 h. After cooling, the solid product was dissolved in ethyl acetate and precipitated with petroleum ether (11, 13) or methanol (12).
References:
Sakhautdinov;Malikova;Sakhautdinova;Abdullin;Nugumanov;Mustafin [Russian Journal of Organic Chemistry,2022,vol. 58,# 12,p. 1984 - 1988][Zh. Org. Khim.,2022,vol. 58,# 12,p. 1387 - 1392]