6-CHLORO-2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE synthesis

1synthesis methods

Product Name:6-CHLORO-2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE
CAS Number:351227-28-6
Molecular formula:C14H8Cl2N2O
Molecular Weight:291.13

88964-99-2 Synthesis

6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine

88964-99-2
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(Chloromethyl)dimethylamine hydrochloride

149409-22-3
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6-CHLORO-2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE

351227-28-6
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Yield:351227-28-6 79%

Reaction Conditions:

Stage #1: 6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine;Vilsmeier reagent in N,N-dimethyl-formamide at 75; for 16 h;Vilsmeier formylation;
Stage #2: with sodium hydroxide

References:

Cooper, Laura C.;Chicchi, Gary G.;Dinnell, Kevin;Elliott, Jason M.;Hollingworth, Gregory J.;Kurtz, Marc M.;Locker, Karen L.;Morrison, Denise;Shaw, Duncan E.;Tsao, Kwei-Lan;Watt, Alan P.;Williams, Angela R.;Swain, Christopher J. [Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,# 9,p. 1233 - 1236]