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ChemicalBook CAS DataBase List 3-(Trifluoromethoxy)benzoic acid
1014-81-9

3-(Trifluoromethoxy)benzoic acid synthesis

2synthesis methods
-

Yield: 85%

Reaction Conditions:

Stage #1:1-bromo-3-(trifluoromethoxy)benzene with n-butyllithium in diethyl ether;hexane at -75; for 0.75 h;
Stage #2:carbon dioxide in diethyl ether;hexane at -78;Further stages.;

References:

Castagnetti, Eva;Schlosser, Manfred [European Journal of Organic Chemistry,2001,# 4,p. 691 - 695]

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