(3-(Phenylethynyl)phenyl)methanol synthesis

5synthesis methods

Product Name:(3-(Phenylethynyl)phenyl)methanol
CAS Number:123926-88-5
Molecular formula:C15H12O
Molecular Weight:208.26

57455-06-8 Synthesis

57455-06-8
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$19.00/1g

536-74-3 Synthesis

536-74-3
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$10.00/1g

123926-88-5
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Yield:123926-88-5 98%

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;cholin hydroxide at 40; for 2 h;Green chemistry;Sonogashira Cross-Coupling;

Steps:

General procedure for coupling reaction

General procedure: To a 25 mL round-bottom flask equipped with a magnetic bar, phenylacetylene (4.5 mmol), aryl halide (3.0 mmol), Pd(PPh₃)₂Cl₂ ( 2.0 mol%) and ChOH (4.0 mL) were added. Then, the mixture was stirred at 40°C. After being stirred, the reaction mixture was filtered. Then, the filtrate was acidified with 3M HCl aqueous solution, and the aqueous layer was extracted with diethyl ether (3 X 10 mL). The combined organic layers were washed with brine, dried with anhydrous Na₂SO₄, and evaporated under reduced pressure. The crude mixture was purified by column chromatography on silica gel (hexanes/ ethyl acetate).

References:

Jung, Da-Young;Park, Soo Youl;Kim, Seung-Hoi [Bulletin of the Korean Chemical Society,2022,vol. 43,# 1,p. 110 - 116] Location in patent:supporting information

57455-06-8 Synthesis

57455-06-8
157 suppliers
$19.00/1g

637-44-5 Synthesis