3-Oxocyclopentanecarboxylic acid synthesis
- Product Name:3-Oxocyclopentanecarboxylic acid
- CAS Number:98-78-2
- Molecular formula:C6H8O3
- Molecular Weight:128.13
5400-79-3
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$30.00/1g
98-78-2
237 suppliers
$10.00/250mg
Yield:98-78-2 30%
Reaction Conditions:
with sodium hydroxide in ethanol at 20; for 3 h;
Steps:
12 Example 12: Preparation of 3-oxocyclopentane-1-carboxylic acid (49)
Place 3-oxocyclopentane-1-carboxylic acid ethyl ester (1.5g, 9.6mmol, 1eq), NaOH (387mg, 9.6mmol, 21eq) and EtOH (30mL) in a 100ml round bottom single-necked flask, at Stir at room temperature for 3h.TLC monitors the completion of the reaction and removes the solvent under reduced pressureWater (20 mL) was added and extracted with ethyl acetate (1×20 mL).Adjust the aqueous phase to pH=34 with 1M dilute hydrochloric acid,The aqueous phase was then extracted with ethyl acetate (3×30 mL),Combine the organic phases, dry over anhydrous sodium sulfate, filter,The filtrate was concentrated under reduced pressure to obtain the title compound 0.5g, yield: 30%.
References:
Chinese Academy Of Medical Sciences Basis Medical Institute;Zhu Dahai;Zhang Yong;Li Changyin;Han Wanhong;Li Hu;Huang Yan CN111253246, 2020, A Location in patent:Paragraph 0433-0437
41171-91-9
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98-78-2
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500-07-2
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98-78-2
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5621-43-2
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98-78-2
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930-30-3
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98-78-2
237 suppliers
$10.00/250mg