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ChemicalBook CAS DataBase List 3-NITROBENZHYDRAZIDE
618-94-0

3-NITROBENZHYDRAZIDE synthesis

8synthesis methods
-

Yield:618-94-0 96.2%

Reaction Conditions:

with hydrazine hydrate in ethanol at 85; for 4 h;

Steps:

12 Example 12 3-nitrobenzoylhydrazoneSynthesis

Take a 25ml jar, add 5ml of anhydrous ethanol, 0.53gMethyl 3-nitrobenzoate, stirring, 0.5 g hydrazine hydrate,The reaction was refluxed at 85 °C for 4 h. After the TLC monitoring reaction is over,The ethanol and excess hydrazine hydrate were evaporated under reduced pressure. The silica gel column was separated from the methanol 20:1 by methanol to give an off-white solid of 3-nitrobenzoyl hydrazide 0.51 g.Yield 96.2%.

References:

CN107827776,2018,A Location in patent:Paragraph 0068; 0069; 0070; 0071

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