3-Nitro-1H-pyrazole synthesis
- Product Name:3-Nitro-1H-pyrazole
- CAS Number:26621-44-3
- Molecular formula:C3H3N3O2
- Molecular Weight:113.07
7119-95-1
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26621-44-3
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$6.00/5g
Yield:26621-44-3 91%
Reaction Conditions:
in benzonitrile for 2 h;Reflux;
Steps:
A solution of 1 -nitro-1 H-pyrazole (4.23 gm, 37.4 mmol; Oakwood Products, Inc., West Columbia, SC) in benzonitrile (42 ml_) was heated to reflux for 2 hours. After cooling to 45 0C, the reaction mixture, which was starting to precipitate, was poured into 175 ml_ hexanes. A white solid precipitated. This was collected by vacuum filtration, rinsed repeatedly with hexane and dried under high vacuum to afford 3.85 grams (91 %) of (l-27a) as a white solid; 1H NMR (400 MHz, DMSO-d6) δ 13.90 (1 H), 8.01 (1 H), 7.01
References:
PFIZER INC.;BENBOW, John William;LOU, Jihong;PFEFFERKORN, Jeffrey Allen;TU, Meihua Mike WO2010/29461, 2010, A1 Location in patent:Page/Page column 63-64
1820-80-0
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26621-44-3
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$6.00/5g
288-13-1
425 suppliers
$10.00/1g
26621-44-3
222 suppliers
$6.00/5g
