3-IODO-2-METHYLBENZONITRILE synthesis
- Product Name:3-IODO-2-METHYLBENZONITRILE
- CAS Number:52107-66-1
- Molecular formula:C8H6IN
- Molecular Weight:243.04
Yield:52107-68-3 69% ，52107-66-1 6%
Reaction Conditions:
with sulfuric acid;iodine;periodic acid;H-β zeolite in water;acetic acid at 20 - 118; for 6 h;Product distribution / selectivity;Heating / reflux;
Steps:
D.8
The same procedure as in Example 1 was carried out, except that 2-methylcyanobenzene (15.5 g, 0.15 mol) was used as the reactant in Example 1. A conversion of 2-methylcyanobenzene was 82 %; the yields were 1) 69 % for 5-iodo-2-methylcyanobenzene and 2) 6 % for 3-iodo-2-methylcyanobenzene; and a ratio of 1)/2) was 11.5.
References:
EP1595862,2005,A1 Location in patent:Page/Page column 9
69022-35-1
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