ChemicalBook CAS DataBase List 3-FLUOROTHIOANISOLE

3-FLUOROTHIOANISOLE synthesis

7synthesis methods

Product Name:3-FLUOROTHIOANISOLE
CAS Number:658-28-6
Molecular formula:C7H7FS
Molecular Weight:142.19

624-92-0 Synthesis

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Yield: 45% ， 30%

Reaction Conditions:

with potassium tert-butylate in acetonitrile at 50; for 6 h;Sealed tube;

Steps:

4.2.1. Synthetic procedures
General procedure: Aryl fluorides (1.0 mmol), CH3SSCH3 (1.2 mmol), t-BuOK (3.0 mmol) and CH3CN (2 mL) were taken in a 25-ml sealed tube. The reaction mixture was stirred at 50 C for 6 h under air. After cooling to room temperature, the product was diluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL). The extracts were combined and washed by brine (3 × 10 mL), dried over MgSO4, filtered, and evaporated, and purified by chromatography on silica gel to obtain the desired products with ethyl acetate/hexane (v/v = 1:301:100). The products were characterized by their spectral and analytical data and compared with those of the known compounds (See supporting information).

References:

Huang, Dayun;Wu, Xiangmei [Journal of Fluorine Chemistry,2021,vol. 245,art. no. 109778]

624-92-0 Synthesis

624-92-0
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$20.62/5 mL