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ChemicalBook CAS DataBase List 3-FLUORO-4-NITROBENZYL BROMIDE
131858-37-2

3-FLUORO-4-NITROBENZYL BROMIDE synthesis

3synthesis methods
503315-74-0 Synthesis
3-Fluoro-4-nitrobenzyl alcohol  99%

503315-74-0
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Yield: 75%

Reaction Conditions:

with N-Bromosuccinimide;triphenylphosphine in dichloromethane at 20; for 2 h;Product distribution / selectivity;

Steps:

6.A
Part A. Preparation of 4-(bromomethyl)-2-fluoro- 1 -nitrobenzene.; [00539] (3-Fluoro-4-nitrophenol)methanol (1.24g, 7.25mmol) was dissolved in dichloromethane (25mL) and treated with triphenylphosphine (2.281g, 8.70mmol) followed by N-bromosuccinimide (1.548g, 8.70mmol). The mixture was stirred at room temperature for 2h. Water (5OmL) and dichloromethane (4OmL) were added, and the organic layer was separated and dried. The solution was concentrated under vacuum and purified by column chromatography using silica gel eluting with a 5/1 mixture of hexanes/ethyl acetate to provide the title compound as a solid (1.21%, 75%).

References:

Location in patent:Page/Page column 110-111

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