ChemicalBook CAS DataBase List 3-DIMETHYLAMINOBENZYL ALCOHOL

3-DIMETHYLAMINOBENZYL ALCOHOL synthesis

7synthesis methods

Product Name:3-DIMETHYLAMINOBENZYL ALCOHOL
CAS Number:23501-93-1
Molecular formula:C9H13NO
Molecular Weight:151.21

3-(DIMETHYLAMINO)BENZOIC ACID METHYL ESTER

16518-64-2
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$45.00/100mg

23501-93-1
79 suppliers
$45.00/10mg

Yield: 92%

Reaction Conditions:

with hydrogen;sodium methylate;dichloro-bis-[2-(diphenylphosphino)ethylamine]ruthenium in tetrahydrofuran at 100; under 37503.8 Torr; for 2.5 h;Product distribution / selectivity;

Steps:

2.10
Several others esters (see Table 3) were hydrogenated under identical conditions as reported in Table 4 with RuCl₂(L-I)₂. The reaction conditions were identical to those reported above for methyl benzoate.Table 3: Structure and name of substrates used EPO Table 4: Results obtained using the general conditions described above EPO Conversion: (in %, analysed by GC after silylation) of ester to alcohol after 2h 30min. Reaction conditions: Substrate (20 mmol), H₂ gas (50 bars), RuCl₂(L-I)₂ 0.05 mol%, NaOMe 10 mol%, THF (14 mL) at 100⁰C during 2h 30min.

References:

FIRMENICH SA WO2006/106483, 2006, A1 Location in patent:Page/Page column 26-29