3-DIETHYLAMINOPROPYL CHLORIDE HYDROCHLORIDE synthesis
- Product Name:3-DIETHYLAMINOPROPYL CHLORIDE HYDROCHLORIDE
- CAS Number:4535-85-7
- Molecular formula:C7H17Cl2N
- Molecular Weight:186.12
622-93-5
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Yield:4535-85-7 88%
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 20; for 3 h;
Steps:
16.a Step a. 3-Chloro-W,W-diethylpropan-1 -amine hydrochloride
To a stirred solution 3-(diethylamino)propan-1-ol (1 g, 7.63 mmol) in DCM (10 mL) was added SOCI2 (1.1 mL, 15.26 mmol) at 0 °C and the mixture was stirred at rt for 3 h. The reaction was concentrated under reduced pressure to obtain the title compound (1 g, 88%).
References:
WO2018/219478,2018,A1 Location in patent:Page/Page column 80; 81
