ChemicalBook CAS DataBase List 3-CHLOROPHENYLACETONE

3-CHLOROPHENYLACETONE synthesis

11synthesis methods

Product Name:3-CHLOROPHENYLACETONE
CAS Number:14123-60-5
Molecular formula:C9H9ClO
Molecular Weight:168.62

2-Propenoic acid, 3-(3-chlorophenyl)-2-methyl-, (2E)-

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Yield: 81%

Reaction Conditions:

with diphenyl phosphoryl azide;triethylamine in toluene at 25 - 110; for 1.5 h;

Steps:

5 Example 5
30.0 g (152.57 mmol) of (E) -2-methyl-3- (3-chlorophenyl) acrylic acid,200mL of toluene, 42.8g (155.62mmol) of DPPA and 16.2g (160.20mmol) of triethylamine were sequentially added to a 500mL reaction flask, and the reaction was stirred at 25 ° C for 0.5h;Warm to 110 for 1h;100 mL of concentrated hydrochloric acid was added to the reaction solution, and the reaction was incubated for 1.5 h.The reaction solution was cooled to room temperature, and the organic layer was separated. The organic layer was washed with a saturated sodium carbonate solution.The toluene was distilled off under reduced pressure to obtain a yellow oily liquid. The crude product was subjected to rectification to obtain 20.8 g of 1- (3-chlorophenyl) -2-acetone with a yield of 81%.The product was analyzed by gas chromatography and the purity was above 99.5%.

References:

Zhejiang Pharmaceutical College;Jia Shu;Yao Xiaomin;Chen Lei CN110590529, 2019, A Location in patent:Paragraph 0045-0046

108-22-5 Synthesis