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ChemicalBook CAS DataBase List 3-CHLOROPHENYL CYCLOPROPYL KETONE
898789-97-4

3-CHLOROPHENYL CYCLOPROPYL KETONE synthesis

2synthesis methods
-

Yield: 68%

Reaction Conditions:

Stage #1:1-bromo-3-chlorobenzene with n-butyllithium in hexane at 0 - 20; for 4 h;Inert atmosphere;
Stage #2:cyclopropropanecarbonitrile in hexane at 20; for 0.166667 h;Inert atmosphere;
Stage #3: with toluene-4-sulfonic acid in hexane;water at 20; for 0.5 h;Inert atmosphere;

References:

Huang, Huawen;Ji, Xiaochen;Wu, Wanqing;Jiang, Huanfeng [Chemical Communications,2013,vol. 49,# 32,p. 3351 - 3353] Location in patent:supporting information

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