ChemicalBook CAS DataBase List 3-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

3-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE synthesis

5synthesis methods

Product Name:3-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE
CAS Number:477535-43-6
Molecular formula:C8H4ClF3O
Molecular Weight:208.57

3-CHLORO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL

886496-87-3
27 suppliers
$38.88/500mgs:

3-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

477535-43-6
96 suppliers
$40.00/1g

Yield: 62%

Reaction Conditions:

with manganese(IV) oxide in toluene at 50; for 14 h;

Steps:

95.5
(Step 5)A solution of the compound (1.00 g) obtained in step 4 and MnO₂(2.06 g) in toluene (30 mL) was stirred at 50° C. for 12 hr. MnO₂(2.06 g) was further added, and the mixture was stirred at 50° C. for 2 hr. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent; 5% ethyl acetate/hexane) to give 3-chloro-5-(trifluoromethyl)benzaldehyde (0.609 g, 62%) as a pale-yellow oil.¹H-NMR (300 MHz, CDCl₃):δ 7.86 (1H, s), 8.02 (1H, s), 8.04 (1H, s), 10.00 (1H, s)

References:

Shirai, Junya;Morimoto, Shinji;Sugiyama, Hideyuki;Sakauchi, Nobuki;Yoshikawa, Takeshi US2008/275085, 2008, A1 Location in patent:Page/Page column 45-46

328-80-3 Synthesis