ChemicalBook CAS DataBase List 3-CHLORO-2-NITROBENZALDEHYDE

3-CHLORO-2-NITROBENZALDEHYDE synthesis

6synthesis methods

Product Name:3-CHLORO-2-NITROBENZALDEHYDE
CAS Number:22233-52-9
Molecular formula:C7H4ClNO3
Molecular Weight:185.56

77158-86-2
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$40.50/1g

22233-52-9
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$23.00/100mg

Yield: 94%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethaneMolecular sieve;

Steps:

A13.a
Example Al 3 a) Preparation of intermediate 28Pyridinium chlorochromate (67 g, 310 mmol) was added to a suspension of 3-chloro-2- nitrobenzylalcohol (25 g, 129 mmol), molecular sieves (40 g), and diatomaceous earth (40 g) in DCM (500 ml). The r.m. was stirred at r.t. for 2 h and then filtrated over silica (eluent: DCM). The product fractions were collected and the solvent was removed under reduced pressure. The residue was purified by chromatography over silica gel (eluent: DCM). The product fractions were collected and the solvent was evaporated. Yield: 22.5 g of intermediate 28 (94 %).

References:

ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC;BISCHOFF, Fran?ois, Paul;GIJSEN, Henricus, Jacobus, Maria;PIETERS, Serge, Maria, Aloysius;MINNE, Garrett, Berlond WO2010/145883, 2010, A1 Location in patent:Page/Page column 54-55