3-(BROMOMETHYL)BENZOIC ACID synthesis
- Product Name:3-(BROMOMETHYL)BENZOIC ACID
- CAS Number:6515-58-8
- Molecular formula:C8H7BrO2
- Molecular Weight:215.04
99-04-7
448 suppliers
$8.00/100g
6515-58-8
151 suppliers
$5.00/250mg
Yield:6515-58-8 86%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in dichloromethane for 2 h;Reflux;
Steps:
4.1 Step 1. Preparation of 3-bromomethylbenzoic acid (Compound 10)
Methylmethylbenzoic acid (2.0 g, 14.7 mmol)And benzoyl peroxide (BPO, 0.036 g, 0.15 mmol)Was dissolved in dichloromethane (6 mL) and heated to reflux,NBS (2.6 g, 14.7 mmol) was added in portions,Continue to heat reflux 2h,After cooling to room temperature, the reaction was quenched with water (10 mL), extracted with dichloromethane (50 mL), washed with water, washed with saturated NaCl, dried over anhydrous Na2SO4,Concentrated to give a pale yellow solid 2.7 g, yield 86%
References:
Zhejiang University;Sheng Rong;Hu Yongzhou;Cao Ji;Li Shan;Qiu Ni;Zhao Mengdan;Yang Bo;He Qiaojun CN106366078, 2017, A Location in patent:Paragraph 0229; 0230; 0231
614-45-9
229 suppliers
$19.30/5g
99-04-7
448 suppliers
$8.00/100g
6515-58-8
151 suppliers
$5.00/250mg
128-08-5
847 suppliers
$5.00/5 g
99-04-7
448 suppliers
$8.00/100g
123-56-8
503 suppliers
$6.00/25g
6515-58-8
151 suppliers
$5.00/250mg
128-08-5
847 suppliers
$5.00/5 g
99-04-7
448 suppliers
$8.00/100g
6515-58-8
151 suppliers
$5.00/250mg
209743-33-9
4 suppliers
$157.00/10g
6515-58-8
151 suppliers
$5.00/250mg