ChemicalBook CAS DataBase List 3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid

3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid synthesis

4synthesis methods

Product Name:3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid
CAS Number:876379-79-2
Molecular formula:C8H5BrN2O2
Molecular Weight:241.04

1610611-84-1 Synthesis

methyl 3-bromopyrazolo[1,5-a]pyridine-5-carboxylate

1610611-84-1
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3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid

876379-79-2
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$101.00/100mg

Yield:-

Reaction Conditions:

with water;sodium hydroxide in methanol at 20; for 1 h;

Steps:

3-bromopyrazolo[1,5-a]pyridine-5-carboxylic acid

A solution of ester (195 mg, 0.764 mmol, 1 .0 equiv.) in 4 mL MeOH was treated with 1aq. NaOH (2 mL, 2.0 mmol, 2.6 equiv.) at rt, and then allowed to stir at rt for one hour. Concentrated under reduced pressure, then diluted with water and acidified with 4 N aq. HCI. Extracted 3 x 10 mL EtOAc, dried the combined organic extracts with Na2SO4, filtered and the solvent removed under reduced pressure to give the desired acid 1-7, which was taken on without further purification.

References:

WO2014/78802,2014,A1 Location in patent:Page/Page column 80

2459-09-8 Synthesis