ChemicalBook CAS DataBase List 3-BROMO-5-IODOANILINE

3-BROMO-5-IODOANILINE synthesis

5synthesis methods

Product Name:3-BROMO-5-IODOANILINE
CAS Number:31948-87-5
Molecular formula:C6H5BrIN
Molecular Weight:297.92

861601-15-2 Synthesis

861601-15-2
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31948-87-5
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$120.00/250 mg

Yield: 96%

Reaction Conditions:

with iron;acetic acid at 20; for 16 h;

Steps:

1.3
3-Bromo-5-iodoaniline.A mixture of 3-Bromo-5-iodonitrobenzene (4.21 g, 0.0128 mol) and iron powder (3.6g, 0.0642 mol) in glacial acetic acid (50 ml) was stirred at ambient temperature for 16 h. The reaction mixture was then filtered through a pad of celite and washed through with ethyl acetate. The filtrate was evaporated in vacuo to give a brown oil. This was re-dissolved in ethyl acetate, loaded onto a large pad of silica and eluted with ethyl acetate. The filtrate was evaporated in vacuo to afford 3-Bromo-5- iodoaniline as a brown solid (3.67g, 96%) which was used without further purification. ¹H NMR (400MHz,δ,CDCI₃): 3.72(2H,br s), 6.77(1 H,s), 6.95(1 H,s), 7.21(1 H,s).

References:

PROLYSIS LTD. WO2007/148093, 2007, A1 Location in patent:Page/Page column 14-15