3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE synthesis
- Product Name:3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE
- CAS Number:59443-15-1
- Molecular formula:C8H6BrClO2
- Molecular Weight:249.49
98434-18-5
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59443-15-1
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Yield:59443-15-1 77%
Reaction Conditions:
with aluminum (III) chloride at 135;
Steps:
22 Intermediate 95: 1 -(3-bromo-5-chloro-2-hydroxyphenyl)ethanone
To a solution of 2-bromo-4-chlorophenyl acetate (20 g, 80 mmol) was added 1 -(3-bromo-5- chloro-2-hydroxyphenyl)ethanone (17 g, 61 .3 mmol, 77 % yield). The mixture was stirred at 135 °C overnight. Water was then added and the mixture was extracted with ethyl acetate. The organic layer was dried over Na2S04, filtered and purified by chromatography on silica gel (hexane/EtOAc = 1/1 ) to give the desire product 1 -(3-bromo-5-chloro-2- hydroxyphenyl)ethanone (17 g, 61 .3 mmol, 77 % yield) as a yellow solid, m/z: [M + H]+ Calcd for C8H7BrCI02 248.9; Found 249
References:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED;BARBE, Guillaume;BOHNERT, Gary;CALANDRA, Nicholas;LAMBERT III, Millard Hurst;LU, Hongfu;LOBERA, Mercedes;RAMANJULU, Joshi;REN, Feng;YANG, Ting WO2019/63748, 2019, A1 Location in patent:Page/Page column 277-278
1450-74-4
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59443-15-1
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$15.00/1g
695-96-5
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59443-15-1
110 suppliers
$15.00/1g