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ChemicalBook CAS DataBase List 3-BROMO-5-CHLORO-2-FLUOROANILINE
1269232-95-2

3-BROMO-5-CHLORO-2-FLUOROANILINE synthesis

4synthesis methods
1996-30-1 Synthesis
2-Bromo-4-chloro-1-fluorobenzene

1996-30-1
223 suppliers
$5.00/1g

-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
1.2: -78 - 20 °C
2.1: diphenylphosphoranyl azide; triethylamine / toluene / 2 h / 75 - 84 °C
2.2: 0.25 h / 35 °C
3.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 1 h / 20 °C

References:

IRM LLC;NOVARTIS AG;HUANG, Shenlin;JIN, Xianming;LIU, Zuosheng;POON, Daniel;TELLEW, John;WAN, Yongqin;WANG, Xing;XIE, Yongping WO2011/25927, 2011, A1

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