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21900-34-5

3-bromo-4-chlorobenzoyl chloride synthesis

4synthesis methods
42860-10-6 Synthesis
3-Bromo-4-chlorobenzoic acid

42860-10-6
200 suppliers
$7.00/5g

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Yield:21900-34-5 100%

Reaction Conditions:

with thionyl chlorideReflux;

Steps:

(Intermediate 9 Synthesis)

3-bromo-4-chlorobenzoic acid 15.0 g (63.7 mmol) and SOC12 63.7 mL were input into a one-neck 500 mL flask to obtain a mixture. Then, the mixture was refluxed and stirred. After completion of the reaction, the reaction product was subjected to distillation under reduced pressure to remove the solvent from the reaction product. A thus-resulting product was crystallized, to obtain a brown solid compound (intermediate 9) 17.0 g (yield: quant.).

References:

US2020/10460,2020,A1 Location in patent:Paragraph 0092-0093