ChemicalBook CAS DataBase List 3-BROMO-4,5-DIMETHOXY-BENZONITRILE

3-BROMO-4,5-DIMETHOXY-BENZONITRILE synthesis

6synthesis methods

Product Name:3-BROMO-4,5-DIMETHOXY-BENZONITRILE
CAS Number:781654-31-7
Molecular formula:C9H8BrNO2
Molecular Weight:242.07

6948-30-7 Synthesis

6948-30-7
129 suppliers
$45.00/1g

781654-31-7
22 suppliers
$99.70/1g

Yield:781654-31-7 100%

Reaction Conditions:

with formic acid;hydroxylamine hydrochloride;sodium formate at 50 - 120; for 55 h;

Steps:

4.1.1.4.17.1

Step 11 1 g 3-Bromo-4,5-dimethoxybenzaldehyde, 6.5 g sodium formate were dissolved in 50 mL of formic acid and stirred at 95°C. 3.6 g Hydroxylamine hydrochloride was added in portions and the mixture stirred for 4 h at 95°C, 2 days at 50°C and 3 h at 120°C. The mixture was poured on to 700 mL of an almost saturated sodium chloride solution/ice mixture and the p re c i p i ta te i s o l a te d , wa s h e d w i t h wa te r a n d d ri e d t o p ro v i d e 3-bromo-4,5 dimethoxybenzonitrile.Yield: 1 1 g (100% of theory)Analysis: HPLC-MS (method E): R_t: 1 .26 min

References:

WO2011/92128,2011,A1 Location in patent:Page/Page column 41

52805-45-5 Synthesis