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ChemicalBook CAS DataBase List 3-bromo-2,6-difluorobenzoic acid
28314-81-0

3-bromo-2,6-difluorobenzoic acid synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 94 percent / butyllithium; bromine / hexane; tetrahydrofuran / 0.75 h / -75 °C
2: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3: 96 percent / 2,2,6,6-tetramethylpiperidine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C

References:

Schlosser, Manfred;Heiss, Christophe [European Journal of Organic Chemistry,2003,# 23,p. 4618 - 4624]

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