3-Bromo-2,5-difluorobenzaldehyde synthesis
- Product Name:3-Bromo-2,5-difluorobenzaldehyde
- CAS Number:112279-64-8
- Molecular formula:C7H3BrF2O
- Molecular Weight:221
112279-62-6
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Yield:-
Reaction Conditions:
with water;hypophosphorous acid;acetic acid;sodium nitrite at 0 - 20; for 1 h;
Steps:
19.4
4.6 g of 4-amino-3-bromo-2,5-difluorobenzaldehyde, 110 ml_ glacial acetic acid, and 54 ml_ of hypophosphorous acid were placed under nitrogen in an oven-dried flask and chilled to 00C. 1.96 g of sodium nitrite dissolved with 11 ml_ water was added to the reaction mixture from an addition funnel maintaining reaction temperature below 15°C. The mixture was warmed to room temperature and stirred for 1 hour, diluted into 300 ml_ of ice water and extracted 3 times with methylene chloride. The combined organic layers were extracted with water, 2 times with 10% sodium hydroxide, 2 times with water,
References:
PFIZER INC. WO2009/69044, 2009, A1 Location in patent:Page/Page column 91-92
112279-63-7
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112279-64-8
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$58.00/100mg