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499983-77-6

3-bromo-1-methyl-1H-indole-2-carboxylic acid synthesis

3synthesis methods
-

Yield:499983-77-6 85%

Reaction Conditions:

Stage #1: 2,3-dibromo-1-methyl-1H-indolewith tert.-butyl lithium in tetrahydrofuran;hexane at -78; for 0.0833333 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane at -78 - 20;

References:

Liu, Yanbing;Gribble, Gordon W [Tetrahedron Letters,2002,vol. 43,# 40,p. 7135 - 7137]