3-Benzoylbenzyl bromide synthesis
- Product Name:3-Benzoylbenzyl bromide
- CAS Number:22071-24-5
- Molecular formula:C14H11BrO
- Molecular Weight:275.14
643-65-2
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22071-24-5
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Yield: 77%
Reaction Conditions:
with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane at 75; for 6.5 h;
Steps:
7.1
Commercially available 3-methylbenzophenone (4.00 g, 20.4 mmol) was dissolved in carbon tetrachloride (100 mL), and N-bromosuccinimide (4.71 g, 26.5 mmol) and 2,2'-azobisisobutyronitrile (1.00 g, 6.09 mmol) was added to the solution, followed by stirring at 75°C for 6.5 hours. After the reaction mixture was cooled, the precipitates were filterd out. The filtrate was combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:20) to obtain 3-bromomethylbenzophenone (4.31 g, yield 77%).
References:
KYOWA HAKKO KOGYO CO., LTD. EP1724271, 2006, A1 Location in patent:Page/Page column 64
1711-06-4
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22071-24-5
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99-04-7
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22071-24-5
87 suppliers
$46.00/5g