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ChemicalBook CAS DataBase List 3-Amino-4-chlorobenzotrifluoride
121-50-6

3-Amino-4-chlorobenzotrifluoride synthesis

6synthesis methods
-

Yield:121-50-6 13% ，39885-50-2 77%

Reaction Conditions:

with potassium fluoride;ammonia in 1-methyl-pyrrolidin-2-one at 245 - 250; under 22067.2 - 29422.9 Torr; for 10 h;Autoclave;

Steps:

1
Example- 1; N-methylpyrrolidone (1050 ml) was charged in an autoclave along with 102 g anhydrous activated potassium fluoride, 377 g 3,4- dichlorobenzotrifluoride was added. Ammonia (158 g) gas was passed in the reactor from the pressure pot at ambient temperature. The content of the reactor was heated to 245-250°C over a period of 2 hours to get reactor pressure of 30-32 kg/cm2. Excess NH3 was fed from the pressure pot to maintain the reactor pressure at 38-40 kg/cm at 245-250°C liquid temperature. Reaction mixture was maintained at 245-250°C and at 38-40 kg/cm2 pressure for further 8 hours. Reaction mixture was cooled to ambient temperature and NH3 was vented and recovered. Reaction mixture was filtered and on fractionation gave 77% yield of 2-chloro-4- trifluoromethylaniline and 13% yield of 2-chloro-5-trifluoro methyl aniline based on consumed 3,4-dichlorobenzotrifluoride.

References:

GHARDA, Keki Hormusji WO2011/107998, 2011, A1 Location in patent:Page/Page column 17

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