ChemicalBook CAS DataBase List 3-AMINO-2,4,5-TRIFLUOROBENZOIC ACID

3-AMINO-2,4,5-TRIFLUOROBENZOIC ACID synthesis

4synthesis methods

Product Name:3-AMINO-2,4,5-TRIFLUOROBENZOIC ACID
CAS Number:119385-80-7
Molecular formula:C7H4F3NO2
Molecular Weight:191.11

1,2-Benzenedicarbonitrile, 4-amino-3,5,6-trifluoro-

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Yield: 76%

Reaction Conditions:

with hydrogenchloride;water at 100;

Steps:

1-5
0.04 mol of compound of formula (1) is added at room temperature,Add 200 g of concentrated hydrochloric acid, heat up to 100 ° C and keep the raw materials disappear. After the reaction, reduce the reaction solution to about 0 ° C, adjust the pH to 1 ~ 2 with 30% liquid alkali, stir for 1 hour, filter out the solids, and filter the filtrate through 450g. It was extracted with ethyl acetate, and the organic layer was concentrated to a remaining volume of 50 ml. The precipitated solid was collected by filtration and dried to obtain 5.8 g of a compound of formula (2) with a yield of 76%.

References:

Chongqing Jingzhi Pharmaceutical Technology Development Co., Ltd.;Li Qian;Deng Wei;Zhou Lingfeng;Ren Li;Yu Mengjun CN110577469, 2019, A Location in patent:Paragraph 5; 6