3-(Acetylamino)thiophene-2-carboxylic acid synthesis
- Product Name:3-(Acetylamino)thiophene-2-carboxylic acid
- CAS Number:50901-18-3
- Molecular formula:C7H7NO3S
- Molecular Weight:185.2
22288-79-5
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50901-18-3
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Yield:50901-18-3 88%
Reaction Conditions:
with methanol;sodium hydroxide at 20 - 50; for 16 h;Concentration;
Steps:
2; 15
To a solution of methyl 3-acetamidothiQphetie~2-caiboxyiate (0.674 g, 3.47 mmol) in MeOH (20 mL) at RT was added NaOH (0.416 g, 10.4 mmol). The mixture was stirred at 50°C for 16 h then concentrated. 1N HC1 was added and the resulting solid was filtered and dried to give 3 -acetamidothi ophene-2-carboxyii c acid (0.642 g, 88% yield) as a solid. MS (ESI) m/z 186.2 [M+H]+.
References:
WO2019/191451,2019,A1 Location in patent:Paragraph 0194; 0235
22288-78-4
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50901-18-3
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50901-18-3
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50901-18-3
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50901-18-3
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