ChemicalBook CAS DataBase List 3,5-DIMETHOXYPHENYLACETONITRILE

3,5-DIMETHOXYPHENYLACETONITRILE synthesis

14synthesis methods

Product Name:3,5-DIMETHOXYPHENYLACETONITRILE
CAS Number:13388-75-5
Molecular formula:C10H11NO2
Molecular Weight:177.2

7677-24-9 Synthesis

7677-24-9
385 suppliers
$19.00/5g

877-88-3 Synthesis

877-88-3
227 suppliers
$5.00/250mg

13388-75-5
169 suppliers
$6.00/250mg

Yield:13388-75-5 66.7%

Reaction Conditions:

with tetrabutyl ammonium fluoride in acetonitrile; for 6 h;Reflux;

Steps:

1 Synthesis of Intermediate 3,5-dimethoxybenzeneacetonitrile 5

Sequentially 2.310g (0.01mol) 3,5- dimethoxy-4-bromobenzyl,Trimethylsilyl cyanide 1.485g (0.015mol),Tetrabutylammonium fluoride 4.725g (0.015mol) in 100mL of acetonitrile and 30ml three-necked flask,Stirring,Was heated to reflux for 6h,TLC tracking and detection,Cooling to room temperature,The reaction solution was poured into 100mL ice water,Stirring,White solid precipitated,filter,The solid was washed with 50% methanol,Dried to give Compound 5, the yield was 66.7%

References:

CN105503652,2016,A Location in patent:Paragraph 0048; 0049