3,5-Dichloropyridazine synthesis
- Product Name:3,5-Dichloropyridazine
- CAS Number:1837-55-4
- Molecular formula:C4H2Cl2N2
- Molecular Weight:148.98
2,4,4,4-Tetrachlorocrotonaldehyde is dissolved in a solvent, and a mixture of semicarbazide hydrochloride, water, and solvent is added dropwise under controlled temperature conditions. The reaction is stirred for 5 hours. Afterward, the reaction mixture is concentrated under reduced pressure to remove the solvent. Water is added, and the temperature is lowered to 5°C, allowing a solid to precipitate. The solid is filtered and recrystallized using a dichloromethane/petroleum ether mixture, yielding 3,5-dichloropyridazine as a white crystalline solid.
1081808-80-1
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1837-55-4
179 suppliers
$23.00/250mg
Yield:1837-55-4 55%
Reaction Conditions:
with semicarbazide hydrochloride in water;N,N-dimethyl-formamide at 15 - 20; for 49 h;
References:
Gospodinov, Ivan;Klap?tke, Thomas M.;Stierstorfer, J?rg [European Journal of Organic Chemistry,2018,vol. 2018,# 8,p. 1004 - 1010] Location in patent:supporting information
19429-51-7
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$416.00/250mg
1837-55-4
179 suppliers
$23.00/250mg