3,5-DICHLORO-2-HYDROXYBENZALDEHYDE HYDRAZONE synthesis
- Product Name:3,5-DICHLORO-2-HYDROXYBENZALDEHYDE HYDRAZONE
- CAS Number:43002-22-8
- Molecular formula:C7H6Cl2N2O
- Molecular Weight:205.04
90-60-8
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Yield:43002-22-8 96%
Reaction Conditions:
with hydrazine hydrate in methanol; for 3 h;Reflux;
Steps:
3.3 Typical procedure for preparation of hydrazinomethylphenols. Preparation Method III (see Scheme 4)
General procedure: Preparation of 2-(hydrazonomethyl)-4-nitrophenol (SA33). A mixture of methanol (300ml), 2-hydroxy-5-nitrobenzaldehyde (250mg; 1.5mmol), and hydrazine monohydrate (130mg; 4.5mmol) was refluxed for three hours. The solvent was evaporated to a solid residue. This residue was mixed with hot methanol (10ml) and sonicated at 60°C for a few minutes. The resulting mixture was mixed with water (~100ml) and then cooled in ice bath. The resulting insoluble product was separated by filtration, washed with cold water (3×5ml) and dried under reduced pressure to give pure product (230mg; 85%).
References:
Backes, Gregory L.;Neumann, Donna M.;Jursic, Branko S. [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 17,p. 4629 - 4636]