Yield:55933-94-3 96%

Reaction Conditions:

with hydrazine hydrate in methanol at 60 - 65; for 2 h;Green chemistry;Temperature;

Steps:

1-4 Example 1

60 g of methanol was added to a 1000 mL four-necked flask, 100 g of 2,3,5,6-tetrachloropyridine, 31.7 g of hydrazine hydrate, and the temperature was raised to 60 to 65 ° C, and the reaction was kept for about 2 hours.After completion of the reaction, the temperature was lowered to 0 to 5 ° C, stirred for 1 hour, and filtered, and the solid was 2,3,5-trichloro-6-hydrazinylpyridine and dried to obtain 101.6 g of a white solid, yield 96%, content 98.5%.

References:

CN108912043,2018,A Location in patent:Paragraph 0008; 0027-0028; 0030-0031; 0033-0034; 0036-0037