3-(4-NITROPHENOXY)-2-BUTANONE synthesis
- Product Name:3-(4-NITROPHENOXY)-2-BUTANONE
- CAS Number:31707-98-9
- Molecular formula:C10H11NO4
- Molecular Weight:209.2
Yield:31707-98-9 79%
Reaction Conditions:
with tert.-butylhydroperoxide;tetra-(n-butyl)ammonium iodide in water at 60; for 8 h;
Steps:
General experimental procedure:
General procedure: To the stirred solution of Phenol (1.0 mmol) and Tetrabutylammoniumiodide (10mol%) in acetone (41.0 mmol) was added dropwise a solution of 70% TBHP (2.2eq) in water over the period of 5 minitus. The reaction was stirred at 60 C under open air atmosphere for 8h. Completion of the reaction was monitored by thin layer chromatography (TLC) . The reaction mixture was cooled to room temperature and the residue was diluted with water and extracted using ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4 and evaporated to afford the crude product which was purified by column chromatography on silica gel (petroleum ether/ethyl acetate as eluent) to afford the pure product. The product was confirmed by 1H, 13C NMR, IR and Mass spectroscopic analysis.
References:
Santhosh Kumar;Ravikumar;Chinna Ashalu;Rajender Reddy [Tetrahedron Letters,2018,vol. 59,# 1,p. 33 - 37] Location in patent:supporting information
