3,4-DIFLUOROBENZOYLACETONITRILE synthesis
- Product Name:3,4-DIFLUOROBENZOYLACETONITRILE
- CAS Number:71682-97-8
- Molecular formula:C9H5F2NO
- Molecular Weight:181.14
Yield:71682-97-8 97%
Reaction Conditions:
Stage #1: acetonitrilewith lithium diisopropyl amide in tetrahydrofuran at -78; for 0.5 h;
Stage #2: 3,4-difluorobenzoyl chloride in tetrahydrofuran at 20; for 4 h;
References:
Rai, Ganesha;Brimacombe, Kyle R.;Mott, Bryan T.;Urban, Daniel J.;Hu, Xin;Yang, Shyh-Ming;Lee, Tobie D.;Cheff, Dorian M.;Kouznetsova, Jennifer;Benavides, Gloria A.;Pohida, Katie;Kuenstner, Eric J.;Luci, Diane K.;Lukacs, Christine M.;Davies, Douglas R.;Dranow, David M.;Zhu, Hu;Sulikowski, Gary;Moore, William J.;Stott, Gordon M.;Flint, Andrew J.;Hall, Matthew D.;Darley-Usmar, Victor M.;Neckers, Leonard M.;Dang, Chi V.;Waterson, Alex G.;Simeonov, Anton;Jadhav, Ajit;Maloney, David J. [Journal of Medicinal Chemistry,2017,vol. 60,# 22,p. 9184 - 9204] Location in patent:supporting information
40706-98-7
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144267-96-9
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