Yield:-

Reaction Conditions:

with dibromo sulfoxide in dichloromethane at 20; for 16 h;

Steps:

62.B
To a solution of the (3,4,5-Trifluorophenyl)methanol (40 mmol) in CH₂Cl₂ (150 ml), a solution of thionyl bromide (6.16 ml, 80 mmol) in CH₂Cl₂ (50 ml) was added slowly. The reaction mixture stirred at room temperature for 16h and poured into ice-water (200 ml). The organic layer was separated and washed with saturated NaHCO₃ (2x200 ml), water (200 ml), dried (MgSO₄) and evaporated to obtain the corresponding bromo compound as a pale yellow oil in quantitative yield. The crude product was carried forward for the next reaction without further purification.

References:

VALEANT RESEARCH & DEVELOPMENT WO2007/14011, 2007, A2 Location in patent:Page/Page column 91

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