ChemicalBook CAS DataBase List 3,3-dimethylbutanal

3,3-dimethylbutanal synthesis

10synthesis methods

Product Name:3,3-dimethylbutanal
CAS Number:2987-16-8
Molecular formula:C6H12O
Molecular Weight:100.16

3,3-dimethylbutanal is prepared from 3,3-dimethylbutanol obtained by reduction of the corresponding carboxylic acid or 1,2-epoxy-3,3-dimethylbutane, or by hydrolysis of 1-halo-3,3-dimethylbutane.

108-05-4
573 suppliers
$4.00/1000g

507-20-0 Synthesis

507-20-0
364 suppliers
$13.00/25mL

2987-16-8
208 suppliers
$5.00/1g

Yield:2987-16-8 75%

Reaction Conditions:

with Sepabeads EC-HA carrier immobilized aluminum trichloride catalyst in dichloromethane at 5; for 10 h;Temperature;

Steps:

1; 2; 3 Example 3
Using a liquid nitrogen cryogenic device, the 1200 g mass fraction of 26.7% methylene chloride solvent was cooled and cooled to 5 ° C. Further, 400 g of chloro-tert-butane and 500 g of Sepabeads EC-HA carrier were added to immobilize the aluminum trichloride catalyst. The active component content is 16%, after mixing and dissolving, After adding 422.2 g of vinyl acetate and stirring uniformly, the reaction was carried out for 10 hours, the vinyl acetate dropping time was 90 min, the distillation was carried out at 60 ° C for 3 hours, and then ice 176.56 g was added. The reaction temperature was 8 ° C, and then 80 g of sodium carbonate was added, and the pH of the distillate was 10, Distillation at 75 ° C for 4 hours gave a purity of 99.7% of 3,3-dimethylbutanal. The molar yield is 75%, which is higher than the traditional yield of 60%.

References:

Shandong Benyue Biological Technology Co., Ltd.;Chen Liang;Wang Zhendong CN109438200, 2019, A Location in patent:Paragraph 0030-0035

1070-83-3 Synthesis