ChemicalBook CAS DataBase List 3-(2-OXO-BENZOTHIAZOL-3-YL)-PROPIONIC ACID

3-(2-OXO-BENZOTHIAZOL-3-YL)-PROPIONIC ACID synthesis

4synthesis methods

Product Name:3-(2-OXO-BENZOTHIAZOL-3-YL)-PROPIONIC ACID
CAS Number:883-50-1
Molecular formula:C10H9NO3S
Molecular Weight:223.25

3(2H)-Benzothiazolepropanenitrile, 2-oxo-

881-13-0
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3-(2-OXO-BENZOTHIAZOL-3-YL)-PROPIONIC ACID

883-50-1
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Yield:883-50-1 6.22 g

Reaction Conditions:

with hydrogenchloride;water for 4 h;Reflux;

Steps:

Synthesis of β-(N-benzothiazoline-2-one)propionic acid.

4.77 g (90 mmol) of acrylonitrile, 0.056 g (1 mmol) of KOH, and 50 ml of dioxane were added to 4.5 g (30 mmol) of benzothiazoline-2-one. The reaction mixture was boiled for 2 h, squeezed well, transferred into a round-bottom flask, and 85 ml of concentrated HCl were added. The flack content was boiled for 4 h, cooled, filtered off, recrystallized from benzene, and 6.22 g (93%) of the product with melt of 129-131 °C was obtained.

References:

Ashurov;Izotova, L. Yu.;Tashkhodzhaev;Olimova;Ibragimov [Journal of Structural Chemistry,2018,vol. 59,# 3,p. 684 - 688][Zh. Strukt. Kim.,2018,vol. 59,# 3,p. 707 - 711,5]

934-34-9 Synthesis