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ChemicalBook CAS DataBase List 2-(3-Chloro-phenyl)-pyrrolidine
298690-74-1

2-(3-Chloro-phenyl)-pyrrolidine synthesis

3synthesis methods
To a solution of substituted benzoic acid inabsolute ethyl alcohol was slowly added thionyl chloride. The mixture was heated to reflux for 2h, and then cooledto room temperature. The solvent was removed and the solid residuewas dissolved in ethyl acetate, and washed withsaturated NaHCO3 solution. After a series of reactions, 3-(2-chloro-phenyl)-pyrrolidine can be obtained.
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: thionyl chloride / 2 h / Reflux
2: sodium hydride / tetrahydrofuran / 3 h / Heating
3: hydrogenchloride / tetrahydrofuran; water / Reflux
4: acetic acid; sodium tetrahydroborate / methanol / 20 °C / Cooling with ice

References:

Wang, Junwei;Song, Qiao;Xu, Anhua;Bao, Yu;Xu, Yungen;Zhu, Qihua [European Journal of Medicinal Chemistry,2017,vol. 130,p. 15 - 25]

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