ChemicalBook CAS DataBase List 3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN

3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN synthesis

4synthesis methods

Product Name:3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN
CAS Number:64887-40-7
Molecular formula:C16H9NO4
Molecular Weight:279.25

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95-55-6 Synthesis

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Yield:64887-40-7 87%

Reaction Conditions:

with acetic acid in glycerol at 80; for 14 h;Schlenk technique;Green chemistry;

Steps:

Typical experimental procedure for synthesis of 3-(benzo[d]oxazol-2-yl)-2H-chromen-2-one

General procedure: The main synthetic root is described in Scheme 1. A mixture of salicylaldehyde(0.50 mmol), o-aminophenol (0.60 mmol) and ethyl cyanoacetate (0.55 mmol) wasplaced in a 10-mL Schlenk tube, and then, 1 mmol acetic acid and 0.2 mL glycerolwere added. The reaction mixture was stirred at the indicated temperature for 14 h.After completion of the reaction, a solution of Na2CO3and ethanol were added to themixture and vigorously stirred for a while. Finally, the precipitate was filtrated andwashed with 50% ethanol without further purification to afford the corresponding pure compound

References:

Gao, Jiali;Liu, Ao;Li, Minghang;Wang, Yuying;Xiao, Yudi;Lü, Chengwei;An, Yue [Research on Chemical Intermediates,2021,vol. 47,# 8,p. 3179 - 3187]