天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-
299912-61-1

4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)- synthesis

2synthesis methods
-

Yield:299912-61-1 90%

Reaction Conditions:

in water;ethyl acetate;isopropyl alcohol;

Steps:

13 Preparation of N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine

EXAMPLE 13 Preparation of N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (50 g, 160 mmol), 3-ethylaniline (21.34 g, 176 mmol) and propan-2-ol (500 mL) was heated at 78-82° C. for 16 hours. The mixture was cooled to cool to 5-10° C. and stirred for 1 hour. The solid was collected by filtration, and mixed with water (200 mL) and ethyl acetate (500 mL). The mixture was adjusted to pH 10-12 with 50% aqueous sodium hydroxide to give to clear layers. The organic layer was separated and washed with water (200 mL), brine (200 mL) and dried over anhydrous magnesium sulfate, filtered and concentrated to an oil. The oil was allowed to solidify and dried under vacuum at 20-25° C. to give the title product (57.2 g, 90%) as a white solid. mp 72-74° C.; δH (300 MHz; CDCl3) 1.16 (3H, t, J=7.6), 2.58 (2H, q, J=7.6), 3.32 (3H, s), 3.34 (3H, s), 2.01-2.47 (2H, m), 2.08-2.54 (2H, m), 4.07-4.12 (4H, m), 6.91 (1H, d, J=7.6), 7.11 (1H, s), 7.21 (1H, t, J=7.8), 7.35 (1H, s), 7.42 (1H, s), 7.48 (1H, d, J=8.0), 8.13 (1H, bs), 8.58 (1H, s); δC (75.5 MHz; CDCl3) 15.4, 28.8, 59.1, 68.2, 68.9, 70.4, 70.8, 103.0, 108.3, 109.3, 119.7, 121.7, 123.9, 128.8, 138.6, 145.1, 147.0, 148.6, 153.6, 154.4, 156.9; νmax (KBr) cm-1 3136 (s), 1624 (s), 1575 (s), 1535 (s), 1487 (s); m/z 398 (M+H)+(Found: C, 65.64; H, 6.96; N, 10.32. C22H27N3O4.0.25H2O requires C, 65.73; H, 6.90; N, 10.45%).

References:

US6476040,2002,B1

4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)- Related Search: