1H-BenziMidazole-1-carboxylicacid,6-aMino-,1,1-diMethylethylester synthesis

2synthesis methods

Product Name:1H-BenziMidazole-1-carboxylicacid,6-aMino-,1,1-diMethylethylester
CAS Number:297756-32-2
Molecular formula:C12H15N3O2
Molecular Weight:233.27

1H-Benzimidazole-1-carboxylic acid, 6-nitro-, 1,1-dimethylethyl ester

1442459-46-2
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1H-BenziMidazole-1-carboxylicacid,6-aMino-,1,1-diMethylethylester

297756-32-2
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Yield:297756-32-2 1.4 g

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 25; under 2585.81 Torr; for 6 h;

Steps:

3.S-15.2 Step 2.

Under an atmosphere of nitrogen, Pd/C (200.0 mg, 10%) was added to a solution of intermediate SI-30 (1.60 g, 6.08 mmol, 1.0 eq) in MeOH (50 mL). The mixture was degassed under vacuum and purged with H₂several times. The mixture was stirred under H₂(50 psi) at 25° C. for 16 h. Upon completion, the reaction mixture was filtered and concentrated to give SI-31 (1.40 g) as colorless oil which was used in step 3 without further purification.

References:

US2020/278355,2020,A1 Location in patent:Paragraph 0387; 0447; 0449

tert-butyl 5-nitro-1H-benzo[d]imidazole-
1-carboxylate

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297756-31-1 Synthesis

297756-31-1
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$208.00/250mg

297756-32-2
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References