Bicyclo[3.1.0]hexan-3-one, 4-hydroxy-4-methyl-1-(1-methylethyl)-, (1S,4R,5S)- (9CI) synthesis
1synthesis methods
- Product Name:Bicyclo[3.1.0]hexan-3-one, 4-hydroxy-4-methyl-1-(1-methylethyl)-, (1S,4R,5S)- (9CI)
- CAS Number:273406-45-4
- Molecular formula:C10H16O2
- Molecular Weight:168.23
Yield:273406-45-4 62%
Reaction Conditions:
Stage #1: Isopropenyl acetate;(-)-α-thujonewith toluene-4-sulfonic acid for 72 h;Heating;
Stage #2: with osmium(VIII) oxide;4-methylmorpholine N-oxide in acetone;tert-butyl alcohol at 0 - 20; for 9 h;
References:
Sirisoma, Nilantha S.;Hoeld, Karin M.;Casida, John E. [Journal of Agricultural and Food Chemistry,2001,vol. 49,# 4,p. 1915 - 1921]