天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methoxy- (9CI)
262614-64-2

Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methoxy- (9CI) synthesis

1synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
833 suppliers
$13.50/25G

6705-03-9 Synthesis
2-Amino-5-methoxybenzoic acid

6705-03-9
263 suppliers
$9.00/1g

-

Yield:262614-64-2 78%

Reaction Conditions:

with pyridine at 90; for 2.5 h;

Steps:

4.1.2. General method for the synthesis of compounds 11, 12 and 14

General procedure: Di-tert-butyl dicarbonate (Boc2O) (1.1 eq) was added to a solutionof the appropriate amine (1 eq) dissolved in anhydrous pyridine(C 1 M). The mixture was stirred at 90 °C for 1h30, then Boc2O (0.5 eq) was added and the mixture was stirred at 90 °C for1 h. The reaction mixture was quenched with aqueous saturatedNH4Cl, the product was then extracted with EtOAc (3 times) andwashed twice with aqueous saturated NH4Cl, and then once withbrine. The organic layer was dried over MgSO4 and concentrated invacuo. The residue was purified by preparative HPLC to give thedesired product.

References:

Baulard, Alain R.;Biela, Alexandre;Blaise, Mickael;Bourbiaux, Kevin;Cantrelle, Francois-Xavier;Djaout, Kamel;Flipo, Marion;Frita, Rosangela;Hanoulle, Xavier;Herledan, Adrien;Kremer, Laurent;Leroux, Florence;Moune, Martin;Pintiala, Catalin;Piveteau, Catherine;Tanina, Abdalkarim;Vandeputte, Alexandre;Willand, Nicolas;Déprez, Benoit;Fa?on, Léo;Wintjens, René [European Journal of Medicinal Chemistry,2020,vol. 200]

Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methoxy- (9CI) Related Search: