Yield:227616-77-5 95%

Reaction Conditions:

with water;trifluoroacetic acid in dichloromethane at 20;

Steps:

1.H Step H: (S)-3-{[(benzyloxy)carbonyl]amino}-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic Acid (1 h)

tert-Butyl ester 1 g (11.13 g, 28.9 mmol) was dissolved in 1:1 CH₂Cl₂/TFA. 1 mL H₂O was added and the mixture was stirred overnight at rt. The mixture was concentrated and the resultant residue was co-evaporated with CCl₄ (3*). The residual oil was triturated with 1:1 Et₂O/hexanes (100 mL) and the solid (9.0 g, 95%) was collected and dried, to provide 1 h. ¹H NMR (300 MHz, CDCl₃) δ 8.69 (br s, 1H), MS (ESI) 330.3 (M+H⁺); 328.3 (M-H+).

References:

US2004/6065,2004,A1 Location in patent:Page/Page column 21