5-(2-CHLORO-5-NITRO-PHENYL)-FURAN-2-CARBOXYLIC ACID synthesis
1synthesis methods
- Product Name:5-(2-CHLORO-5-NITRO-PHENYL)-FURAN-2-CARBOXYLIC ACID
- CAS Number:207399-28-8
- Molecular formula:C11H6ClNO5
- Molecular Weight:267.62
Yield:207399-28-8 63%
Reaction Conditions:
Stage #1: H2NC6H3(Cl)NO2with sulfuric acid;sodium nitrite at 0 - 4; for 0.5 h;Diazotization;
Stage #2: with hydrogenchloride;urea at 10;Elimination;
Stage #3: 2-furanoic acidwith copper dichloride in water;acetone at 20; for 12 h;Arylation;
References:
Glushkov;Vozyakova;Adamskaya;Gus'kova;Pushkina;Radkevich;Solov'eva [Pharmaceutical Chemistry Journal,1998,vol. 32,# 1,p. 8 - 12]