2-(Trifluoromethyl)benzimidazole synthesis
- Product Name:2-(Trifluoromethyl)benzimidazole
- CAS Number:312-73-2
- Molecular formula:C8H5F3N2
- Molecular Weight:186.13
Yield:312-73-2 100%
Reaction Conditions:
for 4 h;Reflux;
Steps:
1 Example 1
Production of 2-trifluoromethylbenzimidazole
To a 100 mL eggplant-shaped flask equipped with a magnetic stirrer, 10.8 g (100 mmol) of 1,2-phenylenediamine and 17.1 g (150 mmol) of trifluoroacetic acid were added.
The mixture was heated to reflux for 4 hours.
After cooling, the reaction mixture was poured into an aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate.
The ethyl acetate layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 18.7 g of gray crystals. Yield: 100%.
1H-NMR (400 MHz, CDCl3, relative to TMS) δ (ppm): 7.37-7.47 (m, 2H), 7.56 (d, J=7.2 Hz, 1H), 7.90 (d, J=7.8 Hz, 1H), 9.96 (br, 1H).
References:
US2017/197920,2017,A1 Location in patent:Paragraph 1201-1203
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