2-(THIAZOL-4-YL)ETHYLAMINE synthesis
- Product Name:2-(THIAZOL-4-YL)ETHYLAMINE
- CAS Number:7728-74-7
- Molecular formula:C5H8N2S
- Molecular Weight:128.2
![2-[2-(1,3-Thiazol-4-yl)ethyl]-1H-isoindole-1,3(2H)-dione](/CAS/GIF/250258-56-1.gif)
250258-56-1
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Yield:7728-74-7 230 mg
Reaction Conditions:
with hydrazine monohydrate in ethanol at 25 - 70; for 2.5 h;
Steps:
Intermediate 136: 2-thiazol-4-ylethanamine :
[00797] A mixture of 2-(2-thiazol-4-ylethyl)isoindoline-1,3-dione (Intermediate 135, 800 mg, 3.10 mmol) and hydrazine hydrate (316.42 mg, 6.19 mmol, 307.21 uL) in EtOH (10 mL) was heated for 30 minutes at 70°C. The reaction mixture was then stirred at 25°C for another 2 h. Insoluble materials were removed by filtration, volatiles removed under reduced pressure and the residue was purified by reversed-phase HPLC (0.1% NH3*H2O condition) to give the title compound as a brown oil (230 mg). [00798] 1H NMR (400 MHz, DMSO-d6) δ = 9.01 (d, J = 2.0 Hz, 1H), 7.34 (d, J = 1.8 Hz, 1H), 2.88 - 2.78 (m, 4H).
References:
WO2022/32144,2022,A1 Location in patent:Paragraph 00797-00798
1452-15-9
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7728-74-7
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