2-(PHENYLTHIO)NICOTINONITRILE synthesis
1synthesis methods
- Product Name:2-(PHENYLTHIO)NICOTINONITRILE
- CAS Number:35620-68-9
- Molecular formula:C12H8N2S
- Molecular Weight:212.27
Yield:35620-68-9 97%
Reaction Conditions:
Stage #1: thiophenolwith sodium hydride in N,N-dimethyl-formamide;mineral oil at 25; for 1 h;Inert atmosphere;
Stage #2: 2-chloro-3-pyridinecarbonitrile in N,N-dimethyl-formamide;mineral oil at 25; for 16 h;Inert atmosphere;
References:
Melzig, Laurin;Metzger, Albrecht;Knochel, Paul [Chemistry - A European Journal,2011,vol. 17,# 10,p. 2948 - 2956] Location in patent:supporting information; experimental part